A Comparative Study of Impedance versus Optical Label-Free Systems Relative to Labelled Assays in a Predominantly Gi Coupled GPCR (C5aR) Signalling

Profiling ligand function on G-protein coupled receptors (GPCRs) typically involves using transfected cells over-expressing a target of interest, a labelled ligand, and intracellular secondary messenger reporters. In contrast, label-free assays are sensitive enough to allow detection in native cells...

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Detalles Bibliográficos
Autores principales: Halai, Reena, Croker, Daniel E., Suen, Jacky Y., Fairlie, David P., Cooper, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263554/
https://www.ncbi.nlm.nih.gov/pubmed/25585930
http://dx.doi.org/10.3390/bios2030273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263554/
https://www.ncbi.nlm.nih.gov/pubmed/25585930
http://dx.doi.org/10.3390/bios2030273

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