Anti-α4 Antibody Treatment Blocks Virus Traffic to the Brain and Gut Early, and Stabilizes CNS Injury Late in Infection

Four SIV-infected monkeys with high plasma virus and CNS injury were treated with an anti-α4 blocking antibody (natalizumab) once a week for three weeks beginning on 28 days post-infection (late). Infection in the brain and gut were quantified, and neuronal injury in the CNS was assessed by MR spect...

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Detalles Bibliográficos
Autores principales: Campbell, Jennifer H., Ratai, Eva-Maria, Autissier, Patrick, Nolan, David J., Tse, Samantha, Miller, Andrew D., González, R. Gilberto, Salemi, Marco, Burdo, Tricia H., Williams, Kenneth C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263764/
https://www.ncbi.nlm.nih.gov/pubmed/25502752
http://dx.doi.org/10.1371/journal.ppat.1004533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263764/
https://www.ncbi.nlm.nih.gov/pubmed/25502752
http://dx.doi.org/10.1371/journal.ppat.1004533

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