Expression of Suppressor of Cytokine Signaling 1 (SOCS1) Impairs Viral Clearance and Exacerbates Lung Injury during Influenza Infection

Suppressor of cytokine signaling (SOCS) proteins are inducible feedback inhibitors of cytokine signaling. SOCS1(−/−) mice die within three weeks postnatally due to IFN-γ-induced hyperinflammation. Since it is well established that IFN-γ is dispensable for protection against influenza infection, we g...

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Detalles Bibliográficos
Autores principales: Sun, Keer, Salmon, Sharon, Yajjala, Vijaya Kumar, Bauer, Christopher, Metzger, Dennis W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263766/
https://www.ncbi.nlm.nih.gov/pubmed/25500584
http://dx.doi.org/10.1371/journal.ppat.1004560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263766/
https://www.ncbi.nlm.nih.gov/pubmed/25500584
http://dx.doi.org/10.1371/journal.ppat.1004560

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