RB Maintains Quiescence and Prevents Premature Senescence through Upregulation of DNMT1 in Mesenchymal Stromal Cells

Many cell therapies currently being tested are based on mesenchymal stromal cells (MSCs). However, MSCs start to enter the senescent state upon long-term expansion. The role of retinoblastoma (RB) protein in regulating MSC properties is not well studied. Here, we show that RB levels are higher in ea...

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Detalles Bibliográficos
Autores principales: Lin, Shih-Pei, Chiu, Fang-Yao, Wang, Yu, Yen, Men-Luh, Kao, Shou-Yen, Hung, Shih-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264040/
https://www.ncbi.nlm.nih.gov/pubmed/25455074
http://dx.doi.org/10.1016/j.stemcr.2014.10.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264040/
https://www.ncbi.nlm.nih.gov/pubmed/25455074
http://dx.doi.org/10.1016/j.stemcr.2014.10.002

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