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Obligatory Role of Intraluminal O(2)(−) in Acute Endothelin-1 and Angiotensin II Signaling to Mediate Endothelial Dysfunction and MAPK Activation in Guinea-Pig Hearts
We hypothesized that, due to a cross-talk between cytoplasmic O(2)(−)-sources and intraluminally expressed xanthine oxidase (XO), intraluminal O(2)(−) is instrumental in mediating intraluminal (endothelial dysfunction) and cytosolic (p38 and ERK1/2 MAPKs phosphorylation) manifestations of vascular o...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264120/ https://www.ncbi.nlm.nih.gov/pubmed/25350109 http://dx.doi.org/10.3390/ijms151119417 |