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Palmitic Acid-Induced Neuron Cell Cycle G(2)/M Arrest and Endoplasmic Reticular Stress through Protein Palmitoylation in SH-SY5Y Human Neuroblastoma Cells
Obesity-related neurodegenerative diseases are associated with elevated saturated fatty acids (SFAs) in the brain. An increase in SFAs, especially palmitic acid (PA), triggers neuron cell apoptosis, causing cognitive function to deteriorate. In the present study, we focused on the specific mechanism...
Autores principales: | Hsiao, Yung-Hsuan, Lin, Ching-I, Liao, Hsiang, Chen, Yue-Hua, Lin, Shyh-Hsiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264201/ https://www.ncbi.nlm.nih.gov/pubmed/25402647 http://dx.doi.org/10.3390/ijms151120876 |
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