Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation

BACKGROUND: Fitness costs and slower disease progression are associated with a cytolytic T lymphocyte (CTL) escape mutation T242N in Gag in HIV-1-infected individuals carrying HLA-B*57/5801 alleles. However, the impact of different context in diverse HIV-1 strains on the fitness costs due to the T24...

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Detalles Bibliográficos
Autores principales: Liu, Donglai, Zuo, Tao, Hora, Bhavna, Song, Hongshuo, Kong, Wei, Yu, Xianghui, Goonetilleke, Nilu, Bhattacharya, Tanmoy, Perelson, Alan S, Haynes, Barton F, McMichael, Andrew J, Gao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264250/
https://www.ncbi.nlm.nih.gov/pubmed/25407514
http://dx.doi.org/10.1186/s12977-014-0101-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264250/
https://www.ncbi.nlm.nih.gov/pubmed/25407514
http://dx.doi.org/10.1186/s12977-014-0101-0

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