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Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation

BACKGROUND: Fitness costs and slower disease progression are associated with a cytolytic T lymphocyte (CTL) escape mutation T242N in Gag in HIV-1-infected individuals carrying HLA-B*57/5801 alleles. However, the impact of different context in diverse HIV-1 strains on the fitness costs due to the T24...

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Detalles Bibliográficos
Autores principales:	Liu, Donglai, Zuo, Tao, Hora, Bhavna, Song, Hongshuo, Kong, Wei, Yu, Xianghui, Goonetilleke, Nilu, Bhattacharya, Tanmoy, Perelson, Alan S, Haynes, Barton F, McMichael, Andrew J, Gao, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264250/ https://www.ncbi.nlm.nih.gov/pubmed/25407514 http://dx.doi.org/10.1186/s12977-014-0101-0

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