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Moderate Hypoxia Induces β-Cell Dysfunction with HIF-1–Independent Gene Expression Changes
Pancreatic β-cell failure is central to the development and progression of type 2 diabetes. We recently demonstrated that β-cells become hypoxic under high glucose conditions due to increased oxygen consumption and that the pancreatic islets of diabetic mice but not those of control mice are moderat...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264765/ https://www.ncbi.nlm.nih.gov/pubmed/25503986 http://dx.doi.org/10.1371/journal.pone.0114868 |