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Functional and Evolutionary Significance of Human MicroRNA Seed Region Mutations

MicroRNAs have emerged in recent years as important regulators of cell function in both normal and diseased cells. MiRNAs coordinately regulate large suites of target genes by mRNA degradation and/or translational inhibition. The mRNA target specificities of miRNAs in animals are primarily encoded w...

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Detalles Bibliográficos
Autores principales: Hill, Christopher G., Jabbari, Neda, Matyunina, Lilya V., McDonald, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264867/
https://www.ncbi.nlm.nih.gov/pubmed/25501359
http://dx.doi.org/10.1371/journal.pone.0115241