Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner

The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis. Here, we demonstrate that the deubiquitinase Cezanne regulates HIF-1α homeostasis. Loss of Cezanne decreases...

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Detalles Bibliográficos
Autores principales: Bremm, Anja, Moniz, Sonia, Mader, Julia, Rocha, Sonia, Komander, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Scientific Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264929/
https://www.ncbi.nlm.nih.gov/pubmed/25355043
http://dx.doi.org/10.15252/embr.201438850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264929/
https://www.ncbi.nlm.nih.gov/pubmed/25355043
http://dx.doi.org/10.15252/embr.201438850

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