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Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase

The machinery of mitochondrial DNA (mtDNA) maintenance is only partially characterized and is of wide interest due to its involvement in disease. To identify novel components of this machinery, plus other cellular pathways required for mtDNA viability, we implemented a genome-wide RNAi screen in Dro...

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Detalles Bibliográficos
Autores principales: Fukuoh, Atsushi, Cannino, Giuseppe, Gerards, Mike, Buckley, Suzanne, Kazancioglu, Selena, Scialo, Filippo, Lihavainen, Eero, Ribeiro, Andre, Dufour, Eric, Jacobs, Howard T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265055/
https://www.ncbi.nlm.nih.gov/pubmed/24952591
http://dx.doi.org/10.15252/msb.20145117