Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions

OBJECTIVE: Mutations in nuclear-encoded mitochondrial DNA (mtDNA) polymerase (POLG) are known to cause autosomal dominant chronic progressive external ophthalmoplegia (adCPEO) with accumulation of multiple mtDNA deletions in muscles. However, no animal model with a heterozygous Polg mutation represe...

Descripción completa

Detalles Bibliográficos
Autores principales: Fuke, Satoshi, Kametani, Mizue, Yamada, Kazuyuki, Kasahara, Takaoki, Kubota-Sakashita, Mie, Kujoth, Gregory C, Prolla, Tomas A, Hitoshi, Seiji, Kato, Tadafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265062/
https://www.ncbi.nlm.nih.gov/pubmed/25540805
http://dx.doi.org/10.1002/acn3.133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265062/
https://www.ncbi.nlm.nih.gov/pubmed/25540805
http://dx.doi.org/10.1002/acn3.133

Ejemplares similares