High-resolution chromosomal microarray analysis of early-stage human embryonic stem cells reveals an association between X chromosome instability and skewed X inactivation

X chromosome inactivation (XCI) is a dosage compensation mechanism that silences the majority of genes on one X chromosome in each female cell via a random process. Skewed XCI is relevant to many diseases, but the mechanism leading to it remains unclear. Human embryonic stem cells (hESCs) derived fr...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Yumei, Li, Jieliang, Zhu, Detu, Fan, Yong, Li, Shaoying, Sun, Xiaofang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265433/
https://www.ncbi.nlm.nih.gov/pubmed/25506417
http://dx.doi.org/10.1186/2045-3701-4-74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265433/
https://www.ncbi.nlm.nih.gov/pubmed/25506417
http://dx.doi.org/10.1186/2045-3701-4-74

Ejemplares similares