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High-resolution chromosomal microarray analysis of early-stage human embryonic stem cells reveals an association between X chromosome instability and skewed X inactivation

X chromosome inactivation (XCI) is a dosage compensation mechanism that silences the majority of genes on one X chromosome in each female cell via a random process. Skewed XCI is relevant to many diseases, but the mechanism leading to it remains unclear. Human embryonic stem cells (hESCs) derived fr...

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Detalles Bibliográficos
Autores principales:	Luo, Yumei, Li, Jieliang, Zhu, Detu, Fan, Yong, Li, Shaoying, Sun, Xiaofang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265433/ https://www.ncbi.nlm.nih.gov/pubmed/25506417 http://dx.doi.org/10.1186/2045-3701-4-74

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