Ligand Based Pharmacophore Modeling and Virtual Screening Studies to Design Novel HDAC2 Inhibitors

Histone deacetylases 2 (HDAC2), Class I histone deacetylase (HDAC) family, emerged as an important therapeutic target for the treatment of various cancers. A total of 48 inhibitors of two different chemotypes were used to generate pharmacophore model using 3D QSAR pharmacophore generation (HypoGen a...

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Detalles Bibliográficos
Autores principales: Kandakatla, Naresh, Ramakrishnan, Geetha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265523/
https://www.ncbi.nlm.nih.gov/pubmed/25525429
http://dx.doi.org/10.1155/2014/812148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265523/
https://www.ncbi.nlm.nih.gov/pubmed/25525429
http://dx.doi.org/10.1155/2014/812148

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