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Facile construction of substituted pyrimido[4,5-d]pyrimidones by transformation of enaminouracil

The reaction of 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione (1) as a binucleophile with primary aromatic or heterocyclic amines and formaldehyde or aromatic (heterocyclic) aldehydes in a molar ratio (1:1:2) gave the pyrimido[4,5-d]pyrimidin-2,4-dione ring systems 2–5. Treatment of 1 with diamine...

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Detalles Bibliográficos
Autores principales:	Hamama, Wafaa S., Ismail, Mohamed A., Al-Saman, Hanaa A., Zoorob, Hanafi H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265671/ https://www.ncbi.nlm.nih.gov/pubmed/25685408 http://dx.doi.org/10.1016/j.jare.2012.01.001

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