Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice

iRhoms are closely related to rhomboid intramembrane proteases but lack catalytic activity. In mammals iRhoms are known to regulate the trafficking of TACE, the protease that cleaves the membrane bound inflammatory cytokine TNF. We have mapped a spontaneously occurring mouse mutation with a loss of...

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Detalles Bibliográficos
Autores principales: Siggs, Owen M., Grieve, Adam, Xu, Hongmei, Bambrough, Paul, Christova, Yonka, Freeman, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265752/
https://www.ncbi.nlm.nih.gov/pubmed/25395669
http://dx.doi.org/10.1242/bio.201410116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265752/
https://www.ncbi.nlm.nih.gov/pubmed/25395669
http://dx.doi.org/10.1242/bio.201410116

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