Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice

BACKGROUND: Loss-of-function mutations in TBC1D20 cause Warburg Micro syndrome 4 (WARBM4), which is an autosomal recessive syndromic disorder characterized by eye, brain, and genital abnormalities. Blind sterile (bs) mice carry a Tbc1d20-null mutation and exhibit cataracts and testicular phenotypes...

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Detalles Bibliográficos
Autores principales: Park, Anna Kyunglim, Liegel, Ryan P, Ronchetti, Adam, Ebert, Allison D, Geurts, Aron, Sidjanin, Duska J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266191/
https://www.ncbi.nlm.nih.gov/pubmed/25476608
http://dx.doi.org/10.1186/s12863-014-0135-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266191/
https://www.ncbi.nlm.nih.gov/pubmed/25476608
http://dx.doi.org/10.1186/s12863-014-0135-2

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