The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population

BACKGROUND: The transcription factor 7-like 2 (TCF7L2) gene is the most significant genetic risk factor for type 2 diabetes (T2D). Association analyses were performed on participants (n = 751, aged between 30 and 64) in the ISOR population-based study in the city of Oran. Dietary intakes were estima...

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Autores principales: Ouhaibi-Djellouli, Hadjira, Mediene-Benchekor, Sounnia, Lardjam-Hetraf, Sarah Aïcha, Hamani-Medjaoui, Imane, Meroufel, Djabaria Naima, Boulenouar, Houssam, Hermant, Xavier, Saidi-Mehtar, Nadhira, Amouyel, Philippe, Houti, Leila, Goumidi, Louisa, Meirhaeghe, Aline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266211/
https://www.ncbi.nlm.nih.gov/pubmed/25491720
http://dx.doi.org/10.1186/s12863-014-0134-3
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author Ouhaibi-Djellouli, Hadjira
Mediene-Benchekor, Sounnia
Lardjam-Hetraf, Sarah Aïcha
Hamani-Medjaoui, Imane
Meroufel, Djabaria Naima
Boulenouar, Houssam
Hermant, Xavier
Saidi-Mehtar, Nadhira
Amouyel, Philippe
Houti, Leila
Goumidi, Louisa
Meirhaeghe, Aline
author_facet Ouhaibi-Djellouli, Hadjira
Mediene-Benchekor, Sounnia
Lardjam-Hetraf, Sarah Aïcha
Hamani-Medjaoui, Imane
Meroufel, Djabaria Naima
Boulenouar, Houssam
Hermant, Xavier
Saidi-Mehtar, Nadhira
Amouyel, Philippe
Houti, Leila
Goumidi, Louisa
Meirhaeghe, Aline
author_sort Ouhaibi-Djellouli, Hadjira
collection PubMed
description BACKGROUND: The transcription factor 7-like 2 (TCF7L2) gene is the most significant genetic risk factor for type 2 diabetes (T2D). Association analyses were performed on participants (n = 751, aged between 30 and 64) in the ISOR population-based study in the city of Oran. Dietary intakes were estimated using a weekly food frequency questionnaire. RESULTS: The T allele of the rs7903146 single nucleotide polymorphism (SNP) was associated with lower body weight (p = 0.02), lower BMI (p = 0.009), lower waist circumference (p = 0.01) and a lower waist-to-hip ratio (p = 0.02). The T allele was associated with a significantly higher risk of T2D (odds ratio (OR) (95% confidence interval) = 1.55 (1.09–2.20), p = 0.01) and this association was independent of BMI. When considering the T2D risk, there were nominal interactions between the rs7903146 SNP and dessert (p = 0.05) and milk intakes (p = 0.01). The T2D risk was greater in T allele carriers with high dessert and milk intakes (OR = 2.61 (1.51-4.52), p = 0.0006, and 2.46 (1.47-4.12), p = 0.0006, respectively). In subjects with a high dessert intake, the T allele was also associated with higher fasting plasma glucose concentrations (4.89 ± 0.46 mmol/L in TT subjects, 4.72 ± 0.48 mmol/L in CT subjects and 4.78 ± 0.51 mmol/L in CC subjects; p = 0.03). CONCLUSIONS: The T allele of the rs7903146 SNP is associated with a significantly higher risk of T2D in an Algerian population. This association was further strengthened by a high dessert intake, suggesting that gene-diet interactions increase the T2D risk.
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spelling pubmed-42662112014-12-16 The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population Ouhaibi-Djellouli, Hadjira Mediene-Benchekor, Sounnia Lardjam-Hetraf, Sarah Aïcha Hamani-Medjaoui, Imane Meroufel, Djabaria Naima Boulenouar, Houssam Hermant, Xavier Saidi-Mehtar, Nadhira Amouyel, Philippe Houti, Leila Goumidi, Louisa Meirhaeghe, Aline BMC Genet Research Article BACKGROUND: The transcription factor 7-like 2 (TCF7L2) gene is the most significant genetic risk factor for type 2 diabetes (T2D). Association analyses were performed on participants (n = 751, aged between 30 and 64) in the ISOR population-based study in the city of Oran. Dietary intakes were estimated using a weekly food frequency questionnaire. RESULTS: The T allele of the rs7903146 single nucleotide polymorphism (SNP) was associated with lower body weight (p = 0.02), lower BMI (p = 0.009), lower waist circumference (p = 0.01) and a lower waist-to-hip ratio (p = 0.02). The T allele was associated with a significantly higher risk of T2D (odds ratio (OR) (95% confidence interval) = 1.55 (1.09–2.20), p = 0.01) and this association was independent of BMI. When considering the T2D risk, there were nominal interactions between the rs7903146 SNP and dessert (p = 0.05) and milk intakes (p = 0.01). The T2D risk was greater in T allele carriers with high dessert and milk intakes (OR = 2.61 (1.51-4.52), p = 0.0006, and 2.46 (1.47-4.12), p = 0.0006, respectively). In subjects with a high dessert intake, the T allele was also associated with higher fasting plasma glucose concentrations (4.89 ± 0.46 mmol/L in TT subjects, 4.72 ± 0.48 mmol/L in CT subjects and 4.78 ± 0.51 mmol/L in CC subjects; p = 0.03). CONCLUSIONS: The T allele of the rs7903146 SNP is associated with a significantly higher risk of T2D in an Algerian population. This association was further strengthened by a high dessert intake, suggesting that gene-diet interactions increase the T2D risk. BioMed Central 2014-12-10 /pmc/articles/PMC4266211/ /pubmed/25491720 http://dx.doi.org/10.1186/s12863-014-0134-3 Text en © Ouhaibi-Djellouli et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ouhaibi-Djellouli, Hadjira
Mediene-Benchekor, Sounnia
Lardjam-Hetraf, Sarah Aïcha
Hamani-Medjaoui, Imane
Meroufel, Djabaria Naima
Boulenouar, Houssam
Hermant, Xavier
Saidi-Mehtar, Nadhira
Amouyel, Philippe
Houti, Leila
Goumidi, Louisa
Meirhaeghe, Aline
The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population
title The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population
title_full The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population
title_fullStr The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population
title_full_unstemmed The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population
title_short The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population
title_sort tcf7l2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an algerian population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266211/
https://www.ncbi.nlm.nih.gov/pubmed/25491720
http://dx.doi.org/10.1186/s12863-014-0134-3
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