Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator

[Image: see text] Ionizing radiation (IR) triggers mitochondrial overproduction of H(2)O(2) and accumulation of lipid hydroperoxides leading to the induction of apoptotic and necroptotic cell death pathways. Given the high catalytic efficiency of the seleno-enzyme glutathione peroxidase (Gpx) toward...

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Detalles Bibliográficos
Autores principales: Stoyanovsky, Detcho A., Jiang, Jianfei, Murphy, Michael P., Epperly, Michael, Zhang, Xiaolan, Li, Song, Greenberger, Joel, Kagan, Valerian, Bayır, Hülya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266336/
https://www.ncbi.nlm.nih.gov/pubmed/25530831
http://dx.doi.org/10.1021/ml5003635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266336/
https://www.ncbi.nlm.nih.gov/pubmed/25530831
http://dx.doi.org/10.1021/ml5003635

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