In Vivo Phenotypic Screening for Treating Chronic Neuropathic Pain: Modification of C2-Arylethynyl Group of Conformationally Constrained A(3) Adenosine Receptor Agonists

[Image: see text] (N)-Methanocarba adenosine 5′-methyluronamides containing 2-arylethynyl groups were synthesized as A(3) adenosine receptor (AR) agonists and screened in vivo (po) for reduction of neuropathic pain. A small N(6)-methyl group maintained binding affinity, with human > mouse A(3)AR...

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Detalles Bibliográficos
Autores principales: Tosh, Dilip K., Finley, Amanda, Paoletta, Silvia, Moss, Steven M., Gao, Zhan-Guo, Gizewski, Elizabeth T., Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266358/
https://www.ncbi.nlm.nih.gov/pubmed/25422861
http://dx.doi.org/10.1021/jm501021n

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266358/
https://www.ncbi.nlm.nih.gov/pubmed/25422861
http://dx.doi.org/10.1021/jm501021n

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