Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity

The emergence of drug resistant strains of Plasmodium spp. creates a critical need for the development of novel antimalarials. Formation of hemozoin, a crystalline heme detoxification process vital to parasite survival serves as an important drug target. The quinoline antimalarials including chloroq...

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Detalles Bibliográficos
Autores principales: Sandlin, Rebecca D., Fong, Kim Y., Wicht, Kathryn J., Carrell, Holly M., Egan, Timothy J., Wright, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266794/
https://www.ncbi.nlm.nih.gov/pubmed/25516843
http://dx.doi.org/10.1016/j.ijpddr.2014.08.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266794/
https://www.ncbi.nlm.nih.gov/pubmed/25516843
http://dx.doi.org/10.1016/j.ijpddr.2014.08.002

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