Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: Implications for control of drug resistant parasitic nematodes

Our objective was to determine if the resistance mechanism to moxidectin (MOX) is similar of that to ivermectin (IVM) and involves P-glycoproteins (PGPs). Several Caenorhabditis elegans strains were used: an IVM and MOX sensitive strain, 13 PGP deletion strains and the IVM-R strain which shows synth...

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Detalles Bibliográficos
Autores principales: Bygarski, Elizabeth E., Prichard, Roger K., Ardelli, Bernadette F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266813/
https://www.ncbi.nlm.nih.gov/pubmed/25516824
http://dx.doi.org/10.1016/j.ijpddr.2014.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266813/
https://www.ncbi.nlm.nih.gov/pubmed/25516824
http://dx.doi.org/10.1016/j.ijpddr.2014.06.002

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