Cargando…

Protonophore properties of hyperforin are essential for its pharmacological activity

Hyperforin is a pharmacologically active component of the medicinal plant Hypericum perforatum (St. John's wort), recommended as a treatment for a range of ailments including mild to moderate depression. Part of its action has been attributed to TRPC6 channel activation. We found that hyperfori...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sell, Thomas S., Belkacemi, Thabet, Flockerzi, Veit, Beck, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266863/ https://www.ncbi.nlm.nih.gov/pubmed/25511254 http://dx.doi.org/10.1038/srep07500

Ejemplares similares

Penetrating Cations Enhance Uncoupling Activity of Anionic Protonophores in Mitochondria
por: Antonenko, Yuri N., et al.
Publicado: (2013)

Tamoxifen Acts as a Parietal Cell Protonophore
por: Manning, E.H., et al.
Publicado: (2020)

Hyperforin Exhibits Antigenotoxic Activity on Human and Bacterial Cells
por: Imreova, Petronela, et al.
Publicado: (2017)

Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice
por: Pochwat, Bartłomiej, et al.
Publicado: (2018)

Transplacental passage of hyperforin, hypericin, and valerenic acid
por: Spiess, Deborah, et al.
Publicado: (2023)

Active Efflux Leads to Heterogeneous Dissipation of Proton Motive Force by Protonophores in Bacteria
por: Le, Dai, et al.
Publicado: (2021)

Highly Active Halogen Bonding and Chalcogen Bonding Chloride Transporters with Non‐Protonophoric Activity
por: Bickerton, Laura E., et al.
Publicado: (2021)

Mechanism of protonophores-mediated induction of heat-shock response in Escherichia coli
por: Jana, Bimal, et al.
Publicado: (2009)

Dual Protonophore–Chitinase Inhibitors Dramatically Affect O. volvulus Molting
por: Gooyit, Major, et al.
Publicado: (2014)

Bile Acids as Inducers of Protonophore and Ionophore Permeability of Biological and Artificial Membranes
por: Samartsev, Victor N., et al.
Publicado: (2023)

Identification of Inhibitory Ca(2+) Binding Sites in the Upper Vestibule of the Yeast Vacuolar TRP Channel
por: Amini, Mahnaz, et al.
Publicado: (2018)

Fifty Years of Research on Protonophores: Mitochondrial Uncoupling As a Basis for Therapeutic Action
por: Kotova, E. A., et al.
Publicado: (2022)

Novel properties of photofermentative biohydrogen production by purple bacteria Rhodobacter sphaeroides: effects of protonophores and inhibitors of responsible enzymes
por: Gabrielyan, Lilit, et al.
Publicado: (2015)

N-Terminally Glutamate-Substituted Analogue of Gramicidin A as Protonophore and Selective Mitochondrial Uncoupler
por: Sorochkina, Alexandra I., et al.
Publicado: (2012)

The TRPV2 channel mediates Ca2+ influx and the Δ9-THC-dependent decrease in osmotic fragility in red blood cells
por: Belkacemi, Anouar, et al.
Publicado: (2021)

Cytotoxicity, metabolism, and isozyme mapping of the synthetic cannabinoids JWH-200, A-796260, and 5F-EMB-PINACA studied by means of in vitro systems
por: Gampfer, Tanja M., et al.
Publicado: (2021)

Disturbed Presynaptic Ca(2+) Signaling in Photoreceptors in the EAE Mouse Model of Multiple Sclerosis
por: Mukherjee, Amrita, et al.
Publicado: (2020)

Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore
por: Chalmers, Susan, et al.
Publicado: (2011)

Hyperforin improves post-stroke social isolation-induced exaggeration of PSD and PSA via TGF-β
por: Zhang, Yujing, et al.
Publicado: (2019)

Optimization of Light Intensity, Temperature, and Nutrients to Enhance the Bioactive Content of Hyperforin and Rutin in St. John’s Wort
por: Kuo, Chia-Hung, et al.
Publicado: (2020)

Anti-Tumor Activity of Hypericum perforatum L. and Hyperforin through Modulation of Inflammatory Signaling, ROS Generation and Proton Dynamics
por: Menegazzi, Marta, et al.
Publicado: (2020)

St. John’s wort extract and hyperforin protect rat and human pancreatic islets against cytokine toxicity
por: Novelli, Michela, et al.
Publicado: (2013)

Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca(2+)–calmodulin binding
por: Amini, Mahnaz, et al.
Publicado: (2021)

Cavβ3 Regulates Ca(2+) Signaling and Insulin Expression in Pancreatic β-Cells in a Cell-Autonomous Manner
por: Becker, Alexander, et al.
Publicado: (2021)

Accumulation of cytokinins in roots and their export to the shoots of durum wheat plants treated with the protonophore carbonyl cyanide m-chlorophenylhydrazone (CCCP)
por: Kudoyarova, Guzel R., et al.
Publicado: (2014)

Hyperforin Inhibits Akt1 Kinase Activity and Promotes Caspase-Mediated Apoptosis Involving Bad and Noxa Activation in Human Myeloid Tumor Cells
por: Merhi, Faten, et al.
Publicado: (2011)

A comparison of artificial intelligence techniques for predicting hyperforin content in Hypericum perforatum L. in different ecological habitats
por: Saffariha, Maryam, et al.
Publicado: (2021)

Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter
por: Rawling, Tristan, et al.
Publicado: (2020)

Hyperforin and Myrtucommulone Derivatives Act as Natural Modulators of Wnt/β-Catenin Signaling in HCT116 Colon Cancer Cells
por: Knauthe, Aneliya, et al.
Publicado: (2022)

Hyperforin Promotes Post-stroke Neuroangiogenesis via Astrocytic IL-6-Mediated Negative Immune Regulation in the Ischemic Brain
por: Yao, Hua, et al.
Publicado: (2019)

Novel Insights into the Effect of Hyperforin and Photodynamic Therapy with Hypericin on Chosen Angiogenic Factors in Colorectal Micro-Tumors Created on Chorioallantoic Membrane
por: Majerník, Martin, et al.
Publicado: (2019)

Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs
por: El Hamdaoui, Yamina, et al.
Publicado: (2022)

Protective Role of St. John’s Wort and Its Components Hyperforin and Hypericin against Diabetes through Inhibition of Inflammatory Signaling: Evidence from In Vitro and In Vivo Studies
por: Novelli, Michela, et al.
Publicado: (2020)

Hyperforin Ameliorates Imiquimod-Induced Psoriasis-Like Murine Skin Inflammation by Modulating IL-17A–Producing γδ T Cells
por: Zhang, Song, et al.
Publicado: (2021)

No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P‐glycoprotein
por: Zahner, Catherine, et al.
Publicado: (2019)

Hyperforin Enhances Heme Oxygenase-1 Expression Triggering Lipid Peroxidation in BRAF-Mutated Melanoma Cells and Hampers the Expression of Pro-Metastatic Markers
por: Cardile, Alessia, et al.
Publicado: (2023)

Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo
por: Koeberle, Andreas, et al.
Publicado: (2011)

Combined hyperforin and lanicemine treatment instead of ketamine or imipramine restores behavioral deficits induced by chronic restraint stress and dietary zinc restriction in mice
por: Pochwat, Bartłomiej, et al.
Publicado: (2022)

Hyperforin modulates MAPK/CCL11 signaling to reduce the inflammatory response of nasal mucosal epithelial cells caused by allergic rhinitis by targeting BCL6
por: Xu, Chen, et al.
Publicado: (2023)

Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes
por: Žuna, Kristina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_09uknu1qb8t2bhjgrejbnakq19