X-Linked thrombocytopenia causing mutations in WASP (L46P and A47D) impair T cell chemotaxis

BACKGROUND: Mutation in the Wiskott-Aldrich syndrome Protein (WASP) causes Wiskott-Aldrich syndrome (WAS), X-linked thrombocytopenia (XLT) and X-linked congenital neutropenia (XLN). The majority of missense mutations causing WAS and XLT are found in the WH1 (WASP Homology) domain of WASP, known to m...

Descripción completa

Detalles Bibliográficos
Autores principales: Jain, Neeraj, Tan, Jun Hou, Feng, Shijin, George, Bhawana, Thanabalu, Thirumaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266975/
https://www.ncbi.nlm.nih.gov/pubmed/25200405
http://dx.doi.org/10.1186/s12929-014-0091-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266975/
https://www.ncbi.nlm.nih.gov/pubmed/25200405
http://dx.doi.org/10.1186/s12929-014-0091-1

Ejemplares similares