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E5564 inhibits immunosuppressive cytokine IL-10 induction promoted by HIV-1 Tat protein
BACKGROUND: In HIV-1 infected patients, production of interleukin-10 (IL-10), a highly immunosuppressive cytokine, is associated with progression of infection toward AIDS. HIV-1 Tat protein, by interacting with TLR4-MD2 at the membrane level, induces IL-10 production by primary human monocytes and m...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267154/ https://www.ncbi.nlm.nih.gov/pubmed/25471526 http://dx.doi.org/10.1186/s12985-014-0214-z |