Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities

GTPases and kinases are two predominant signaling modules that regulate cell fate. Dysregulation of Ras, a GTPase, and the three eponymous kinases that form key nodes of the associated phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K)/AKT/mTOR pathway have been implicated in many cancers, includ...

Descripción completa

Detalles Bibliográficos
Autores principales: Hubbard, Paul A., Moody, Colleen L., Murali, Ramachandran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267178/
https://www.ncbi.nlm.nih.gov/pubmed/25566081
http://dx.doi.org/10.3389/fphys.2014.00478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267178/
https://www.ncbi.nlm.nih.gov/pubmed/25566081
http://dx.doi.org/10.3389/fphys.2014.00478

Ejemplares similares