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Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities

GTPases and kinases are two predominant signaling modules that regulate cell fate. Dysregulation of Ras, a GTPase, and the three eponymous kinases that form key nodes of the associated phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K)/AKT/mTOR pathway have been implicated in many cancers, includ...

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Detalles Bibliográficos
Autores principales:	Hubbard, Paul A., Moody, Colleen L., Murali, Ramachandran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267178/ https://www.ncbi.nlm.nih.gov/pubmed/25566081 http://dx.doi.org/10.3389/fphys.2014.00478

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