Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia

Cell fate can be controlled through asymmetric division and segregation of protein determinants. But the regulation of this process in the hematopoietic system is poorly understood. Here we show that the dynein binding protein Lis1 (Pafah1b1) is critically required for blood formation and hematopoie...

Descripción completa

Detalles Bibliográficos
Autores principales: Zimdahl, Bryan, Ito, Takahiro, Blevins, Allen, Bajaj, Jeevisha, Konuma, Takaaki, Weeks, Joi, Koechlein, Claire S., Kwon, Hyog Young, Arami, Omead, Rizzieri, David, Broome, H. Elizabeth, Chuah, Charles, Oehler, Vivian G., Sasik, Roman, Hardiman, Gary, Reya, Tannishtha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267534/
https://www.ncbi.nlm.nih.gov/pubmed/24487275
http://dx.doi.org/10.1038/ng.2889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267534/
https://www.ncbi.nlm.nih.gov/pubmed/24487275
http://dx.doi.org/10.1038/ng.2889

Ejemplares similares