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Locating the uracil-5-yl radical formed upon photoirradiation of 5-bromouracil-substituted DNA

In a previous study, we found that 2-deoxyribonolactone is effectively generated in the specific 5-bromouracil ((Br)U)-substituted sequence 5′-(G/C)[A](n) (= 1,2)(Br)U(Br)U-3′ and proposed that a formed uracil-5-yl radical mainly abstracts the C1′ hydrogen from the 5′-side of (Br)U(Br)U under 302-nm...

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Detalles Bibliográficos
Autores principales: Hashiya, Fumitaka, Saha, Abhijit, Kizaki, Seiichiro, Li, Yue, Sugiyama, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267621/
https://www.ncbi.nlm.nih.gov/pubmed/25398904
http://dx.doi.org/10.1093/nar/gku1133