Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis

We have shown that Sp1 phosphorylation at Thr739 decreases its DNA-binding activity. In this study, we found that phosphorylation of Sp1 at Thr739 alone is necessary, but not sufficient for the inhibition of its DNA-binding activity during mitosis. We demonstrated that Pin1 could be recruited to the...

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Detalles Bibliográficos
Autores principales: Yang, Hang-Che, Chuang, Jian-Ying, Jeng, Wen-Yih, Liu, Chia-I, Wang, Andrew H.-J., Lu, Pei-Jung, Chang, Wen-Chang, Hung, Jan-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267622/
https://www.ncbi.nlm.nih.gov/pubmed/25398907
http://dx.doi.org/10.1093/nar/gku1145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267622/
https://www.ncbi.nlm.nih.gov/pubmed/25398907
http://dx.doi.org/10.1093/nar/gku1145

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