The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition

LEF/TCFs direct the final step in Wnt/β-catenin signalling by recruiting β-catenin to genes for activation of transcription. Ancient, non-vertebrate TCFs contain two DNA binding domains, a High Mobility Group box for recognition of the Wnt Response Element (WRE; 5′-CTTTGWWS-3′) and the C-clamp domai...

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Detalles Bibliográficos
Autores principales: Hoverter, Nate P., Zeller, Michael D., McQuade, Miriam M., Garibaldi, Angela, Busch, Anke, Selwan, Elizabeth M., Hertel, Klemens J., Baldi, Pierre, Waterman, Marian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267635/
https://www.ncbi.nlm.nih.gov/pubmed/25414359
http://dx.doi.org/10.1093/nar/gku1186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267635/
https://www.ncbi.nlm.nih.gov/pubmed/25414359
http://dx.doi.org/10.1093/nar/gku1186

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