A 5′, 8-cyclo-2′-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β

5′,8-cyclo-2′-deoxypurines (cdPus) are common forms of oxidized DNA lesions resulting from endogenous and environmental oxidative stress such as ionizing radiation. The lesions can only be repaired by nucleotide excision repair with a low efficiency. This results in their accumulation in the genome...

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Detalles Bibliográficos
Autores principales: Xu, Meng, Lai, Yanhao, Jiang, Zhongliang, Terzidis, Michael A., Masi, Annalisa, Chatgilialoglu, Chryssostomos, Liu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267656/
https://www.ncbi.nlm.nih.gov/pubmed/25428354
http://dx.doi.org/10.1093/nar/gku1239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267656/
https://www.ncbi.nlm.nih.gov/pubmed/25428354
http://dx.doi.org/10.1093/nar/gku1239

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