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Identification of tri-phosphatase activity in the biogenesis of retroviral microRNAs and RNAP III-generated shRNAs

Transcripts possessing a 5′-triphosphate are a hallmark of viral transcription and can trigger the host antiviral response. 5′-triphosphates are also found on common host transcripts transcribed by RNA polymerase III (RNAP III), yet how these transcripts remain non-immunostimulatory is incompletely...

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Detalles Bibliográficos
Autores principales: Burke, James M., Bass, Clovis R., Kincaid, Rodney P., Sullivan, Christopher S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267658/
https://www.ncbi.nlm.nih.gov/pubmed/25428356
http://dx.doi.org/10.1093/nar/gku1247