Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application

Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of migration and invasion, stem cell like characteristics and therapeutic resistance. Notch signaling regulates cell-cell connection, cell polarity and motility during organ development. Recent studies demonstrate...

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Autores principales: Yuan, Xun, Wu, Hua, Han, Na, Xu, Hanxiao, Chu, Qian, Yu, Shiying, Chen, Yuan, Wu, Kongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267749/
https://www.ncbi.nlm.nih.gov/pubmed/25477004
http://dx.doi.org/10.1186/s13045-014-0087-z
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author Yuan, Xun
Wu, Hua
Han, Na
Xu, Hanxiao
Chu, Qian
Yu, Shiying
Chen, Yuan
Wu, Kongming
author_facet Yuan, Xun
Wu, Hua
Han, Na
Xu, Hanxiao
Chu, Qian
Yu, Shiying
Chen, Yuan
Wu, Kongming
author_sort Yuan, Xun
collection PubMed
description Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of migration and invasion, stem cell like characteristics and therapeutic resistance. Notch signaling regulates cell-cell connection, cell polarity and motility during organ development. Recent studies demonstrate that Notch signaling plays an important role in lung cancer initiation and cross-talks with several transcriptional factors to enhance EMT, contributing to the progression of non-small cell lung cancer (NSCLC). Correspondingly, blocking of Notch signaling inhibits NSCLC migration and tumor growth by reversing EMT. Clinical trials have showed promising effect in some cancer patients received treatment with Notch1 inhibitor. This review attempts to provide an overview of the Notch signal in NSCLC: its biological significance and therapeutic application. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-014-0087-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-42677492014-12-17 Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application Yuan, Xun Wu, Hua Han, Na Xu, Hanxiao Chu, Qian Yu, Shiying Chen, Yuan Wu, Kongming J Hematol Oncol Review Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of migration and invasion, stem cell like characteristics and therapeutic resistance. Notch signaling regulates cell-cell connection, cell polarity and motility during organ development. Recent studies demonstrate that Notch signaling plays an important role in lung cancer initiation and cross-talks with several transcriptional factors to enhance EMT, contributing to the progression of non-small cell lung cancer (NSCLC). Correspondingly, blocking of Notch signaling inhibits NSCLC migration and tumor growth by reversing EMT. Clinical trials have showed promising effect in some cancer patients received treatment with Notch1 inhibitor. This review attempts to provide an overview of the Notch signal in NSCLC: its biological significance and therapeutic application. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-014-0087-z) contains supplementary material, which is available to authorized users. BioMed Central 2014-12-05 /pmc/articles/PMC4267749/ /pubmed/25477004 http://dx.doi.org/10.1186/s13045-014-0087-z Text en © Yuan et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Yuan, Xun
Wu, Hua
Han, Na
Xu, Hanxiao
Chu, Qian
Yu, Shiying
Chen, Yuan
Wu, Kongming
Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application
title Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application
title_full Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application
title_fullStr Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application
title_full_unstemmed Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application
title_short Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application
title_sort notch signaling and emt in non-small cell lung cancer: biological significance and therapeutic application
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267749/
https://www.ncbi.nlm.nih.gov/pubmed/25477004
http://dx.doi.org/10.1186/s13045-014-0087-z
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