Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair

The presence of phosphorylated histone H2AX (γ-H2AX) is associated with the local activation of DNA-damage repair pathways. Although γ-H2AX deregulation in cancer has previously been reported, the molecular mechanism involved and its relationship with other histone modifications remain largely unkno...

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Detalles Bibliográficos
Autores principales: Sone, Kenbun, Piao, Lianhua, Nakakido, Makoto, Ueda, Koji, Jenuwein, Thomas, Nakamura, Yusuke, Hamamoto, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268694/
https://www.ncbi.nlm.nih.gov/pubmed/25487737
http://dx.doi.org/10.1038/ncomms6691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268694/
https://www.ncbi.nlm.nih.gov/pubmed/25487737
http://dx.doi.org/10.1038/ncomms6691

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