Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1

Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1)...

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Detalles Bibliográficos
Autores principales: Fusi, Camilla, Materazzi, Serena, Benemei, Silvia, Coppi, Elisabetta, Trevisan, Gabriela, Marone, Ilaria M., Minocci, Daiana, De Logu, Francesco, Tuccinardi, Tiziano, Di Tommaso, Maria Rosaria, Susini, Tommaso, Moneti, Gloriano, Pieraccini, Giuseppe, Geppetti, Pierangelo, Nassini, Romina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268712/
https://www.ncbi.nlm.nih.gov/pubmed/25484020
http://dx.doi.org/10.1038/ncomms6736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268712/
https://www.ncbi.nlm.nih.gov/pubmed/25484020
http://dx.doi.org/10.1038/ncomms6736

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