Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

LRRK2, a gene relevant to Parkinson's disease, encodes a scaffolding protein with both GTPase and kinase activities. LRRK2 protein is itself phosphorylated and therefore subject to regulation by cell signaling but the kinase(s) responsible for this event have not been definitively identified. H...

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Detalles Bibliográficos
Autores principales: Chia, Ruth, Haddock, Sara, Beilina, Alexandra, Rudenko, Iakov N, Mamais, Adamantios, Kaganovich, Alice, Li, Yan, Kumaran, Ravindran, Nalls, Michael A, Cookson, Mark R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268884/
https://www.ncbi.nlm.nih.gov/pubmed/25500533
http://dx.doi.org/10.1038/ncomms6827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268884/
https://www.ncbi.nlm.nih.gov/pubmed/25500533
http://dx.doi.org/10.1038/ncomms6827

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