Constitutive and ligand-induced EGFR signaling triggers distinct and mutually exclusive downstream signaling networks

EGFR overexpression plays an important oncogenic role in cancer. Regular EGFR protein levels are increased in cancer cells and the receptor then becomes constitutively active. However, downstream signals generated by constitutively activated EGFR are unknown. Here we report that the overexpressed EG...

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Detalles Bibliográficos
Autores principales: Chakraborty, Sharmistha, Li, Li, Puliyappadamba, VineshkumarThidil, Guo, Gao, Hatanpaa, Kimmo J., Mickey, Bruce, Souza, Rhonda F., Vo, Peggy, Herz, Joachim, Chen, Mei-Ru, Boothman, David A., Pandita, Tej K., Wang, David H., Sen, Ganes C., Habib, Amyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268886/
https://www.ncbi.nlm.nih.gov/pubmed/25503978
http://dx.doi.org/10.1038/ncomms6811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268886/
https://www.ncbi.nlm.nih.gov/pubmed/25503978
http://dx.doi.org/10.1038/ncomms6811

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