Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

INTRODUCTION: Recent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injection of rapamycin reduces the severity of experimental osteoarthritis in a murine model of OA in vivo....

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Detalles Bibliográficos
Autores principales: Takayama, Koji, Kawakami, Yohei, Kobayashi, Makoto, Greco, Nick, Cummins, James H, Matsushita, Takehiko, Kuroda, Ryosuke, Kurosaka, Masahiro, Fu, Freddie H, Huard, Johnny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269094/
https://www.ncbi.nlm.nih.gov/pubmed/25403236
http://dx.doi.org/10.1186/s13075-014-0482-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269094/
https://www.ncbi.nlm.nih.gov/pubmed/25403236
http://dx.doi.org/10.1186/s13075-014-0482-4

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