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Spartan deficiency causes genomic instability and progeroid phenotypes

Spartan (also known as DVC1 and C1orf124) is a PCNA-interacting protein implicated in translesion synthesis, a DNA damage tolerance process that allows the DNA replication machinery to replicate past nucleotide lesions. However, the physiological relevance of Spartan has not been established. Here w...

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Detalles Bibliográficos
Autores principales: Maskey, Reeja S., Kim, Myoung Shin, Baker, Darren J., Childs, Bennett, Malureanu, Liviu A., Jeganathan, Karthik B., Machida, Yuka, van Deursen, Jan M., Machida, Yuichi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269170/
https://www.ncbi.nlm.nih.gov/pubmed/25501849
http://dx.doi.org/10.1038/ncomms6744