Cargando…

Spartan deficiency causes genomic instability and progeroid phenotypes

Spartan (also known as DVC1 and C1orf124) is a PCNA-interacting protein implicated in translesion synthesis, a DNA damage tolerance process that allows the DNA replication machinery to replicate past nucleotide lesions. However, the physiological relevance of Spartan has not been established. Here w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maskey, Reeja S., Kim, Myoung Shin, Baker, Darren J., Childs, Bennett, Malureanu, Liviu A., Jeganathan, Karthik B., Machida, Yuka, van Deursen, Jan M., Machida, Yuichi J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269170/ https://www.ncbi.nlm.nih.gov/pubmed/25501849 http://dx.doi.org/10.1038/ncomms6744

Ejemplares similares

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis
por: Maskey, Reeja S., et al.
Publicado: (2017)

Regulation of error-prone translesion synthesis by Spartan/C1orf124
por: Kim, Myoung Shin, et al.
Publicado: (2013)

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
por: Jeganathan, Karthik, et al.
Publicado: (2007)

Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice
por: Baker, Darren J., et al.
Publicado: (2006)

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation
por: Wijshake, Tobias, et al.
Publicado: (2012)

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation
por: van Ree, Janine H., et al.
Publicado: (2010)

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression
por: Ricke, Robin M., et al.
Publicado: (2012)

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis
por: Malureanu, Liviu, et al.
Publicado: (2010)

Reprogramming to Pluripotency Can Conceal Somatic Cell Chromosomal Instability
por: Hamada, Masakazu, et al.
Publicado: (2012)

Cdc20 Is Critical for Meiosis I and Fertility of Female Mice
por: Jin, Fang, et al.
Publicado: (2010)

Phylarchus and the Spartan revolution
por: Africa, Thomas W.
Publicado: (1961)

Genomic instability and DNA replication defects in progeroid syndromes
por: Burla, Romina, et al.
Publicado: (2018)

The progeroid gene BubR1 regulates axon myelination and motor function
por: Choi, Chan-Il, et al.
Publicado: (2016)

Ran-dependent docking of importin-β to RanBP2/Nup358 filaments is essential for protein import and cell viability
por: Hamada, Masakazu, et al.
Publicado: (2011)

The Progeroid Phenotype of Ku80 Deficiency Is Dominant over DNA-PK(CS) Deficiency
por: Reiling, Erwin, et al.
Publicado: (2014)

Progeroide Syndrome: Alterung, Hautalterung und Mechanismen progeroider Erkrankungen
por: Koschitzki, Kevin, et al.
Publicado: (2023)

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
por: Baker, Darren J., et al.
Publicado: (2012)

Spartan 3 FPGA Family: Introduction and Ordering Information
por: XILINX. San Jose
Publicado: (2007)

Spartan Face Mask Detection and Facial Recognition System
por: Song, Ziwei, et al.
Publicado: (2022)

p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes
por: Tivey, Hannah S. E., et al.
Publicado: (2012)

FPGA prototyping by VHDL examples: Xilinx Spartan-3 version
por: Chu, Pong P
Publicado: (2008)

FPGA prototyping by Verilog examples: Xilinx Spartan-3 version
por: Chu, Pong P
Publicado: (2008)

Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency
por: Barnhoorn, Sander, et al.
Publicado: (2014)

Myotonic Dystrophy—A Progeroid Disease?
por: Meinke, Peter, et al.
Publicado: (2018)

Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes
por: Kato, Hisaya, et al.
Publicado: (2022)

Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems
por: Alden, Kieran, et al.
Publicado: (2013)

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation
por: Babu, J. Ramesh, et al.
Publicado: (2003)

sFRP3 inhibition improves age‐related cellular changes in BubR1 progeroid mice
por: Cho, Chang Hoon, et al.
Publicado: (2019)

Fontaine progeroid syndrome—A case report
por: Lally, Sinéad, et al.
Publicado: (2022)

Insights into aging from progeroid syndrome epigenetics
por: Bejaoui, Yosra, et al.
Publicado: (2023)

SPaRTAN, a computational framework for linking cell-surface receptors to transcriptional regulators
por: Ma, Xiaojun, et al.
Publicado: (2021)

Correction: Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems
por: Alden, Kieran, et al.
Publicado: (2013)

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer
por: Weaver, Robbyn L, et al.
Publicado: (2016)

Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxide
por: Akinci, Baris, et al.
Publicado: (2017)

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
por: Baker, Darren J., et al.
Publicado: (2016)

Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome
por: Pignolo, Robert J., et al.
Publicado: (2020)

Validation of the Spartan RXCYP2C19 Genotyping Assay Utilizing Blood Samples
por: Davis, Brittney H., et al.
Publicado: (2019)

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model
por: Koshimizu, Eriko, et al.
Publicado: (2011)

Epigenomic signature of accelerated ageing in progeroid Cockayne syndrome
por: Crochemore, Clément, et al.
Publicado: (2023)

The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside
por: Birkisdóttir, María B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uk9255h24h2ha37hagusf6g9qa