The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid

In the development of central nervous system (CNS)-targeted drugs, the prediction of human CNS target exposure is a big challenge. Cerebrospinal fluid (CSF) concentrations have often been suggested as a ‘good enough’ surrogate for brain extracellular fluid (brain(ECF), brain target site) concentrati...

Descripción completa

Detalles Bibliográficos
Autores principales: Westerhout, Joost, Smeets, Jean, Danhof, Meindert, de Lange, Elizabeth C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269305/
https://www.ncbi.nlm.nih.gov/pubmed/23539188
http://dx.doi.org/10.1007/s10928-013-9314-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269305/
https://www.ncbi.nlm.nih.gov/pubmed/23539188
http://dx.doi.org/10.1007/s10928-013-9314-4

Ejemplares similares