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The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid
In the development of central nervous system (CNS)-targeted drugs, the prediction of human CNS target exposure is a big challenge. Cerebrospinal fluid (CSF) concentrations have often been suggested as a ‘good enough’ surrogate for brain extracellular fluid (brain(ECF), brain target site) concentrati...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269305/ https://www.ncbi.nlm.nih.gov/pubmed/23539188 http://dx.doi.org/10.1007/s10928-013-9314-4 |