Targeting the HA2 subunit of influenza A virus hemagglutinin via CD40L provides universal protection against diverse subtypes

The influenza viral hemagglutinin (HA) is comprised of two subunits. Current influenza vaccine predominantly induces neutralizing antibodies (Abs) against the HA1 subunit, which is constantly evolving in unpredictable fashion. The other subunit, HA2, however, is highly conserved but largely shielded...

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Detalles Bibliográficos
Autores principales: Fan, X, Hashem, A M, Chen, Z, Li, C, Doyle, T, Zhang, Y, Yi, Y, Farnsworth, A, Xu, K, Li, Z, He, R, Li, X, Wang, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269809/
https://www.ncbi.nlm.nih.gov/pubmed/25052763
http://dx.doi.org/10.1038/mi.2014.59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269809/
https://www.ncbi.nlm.nih.gov/pubmed/25052763
http://dx.doi.org/10.1038/mi.2014.59

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