Construction of a synthetic phage-displayed Nanobody library with CDR3 regions randomized by trinucleotide cassettes for diagnostic applications

BACKGROUND: Nanobodies (Nbs) have proved their great value as therapeutic molecules and clinical diagnostic tools. Although the routine procedure to obtain Nbs is to immunize camels with antigens, it is unavailable to immunize a camel when the antigens are highly toxic, pathogenic or nonimmunogenic....

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Detalles Bibliográficos
Autores principales: Yan, Junrong, Li, Guanghui, Hu, Yonghong, Ou, Weijun, Wan, Yakun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269866/
https://www.ncbi.nlm.nih.gov/pubmed/25496223
http://dx.doi.org/10.1186/s12967-014-0343-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269866/
https://www.ncbi.nlm.nih.gov/pubmed/25496223
http://dx.doi.org/10.1186/s12967-014-0343-6

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