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Anesthetic Diffusion Through Lipid Membranes Depends on the Protonation Rate

Hundreds of substances possess anesthetic action. However, despite decades of research and tests, a golden rule is required to reconcile the diverse hypothesis behind anesthesia. What makes an anesthetic to be local or general in the first place? The specific targets on proteins, the solubility in l...

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Detalles Bibliográficos
Autores principales: Pérez-Isidoro, Rosendo, Sierra-Valdez, F. J., Ruiz-Suárez, J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269894/
https://www.ncbi.nlm.nih.gov/pubmed/25520016
http://dx.doi.org/10.1038/srep07534