The accessory helix of complexin functions by stabilizing central helix secondary structure

The presynaptic protein complexin (CPX) is a critical regulator of synaptic vesicle fusion, but the mechanisms underlying its regulatory effects are not well understood. Its highly conserved central helix (CH) directly binds the ternary SNARE complex and is required for all known CPX functions. The...

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Detalles Bibliográficos
Autores principales: Radoff, Daniel T, Dong, Yongming, Snead, David, Bai, Jihong, Eliezer, David, Dittman, Jeremy S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270070/
https://www.ncbi.nlm.nih.gov/pubmed/25383924
http://dx.doi.org/10.7554/eLife.04553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270070/
https://www.ncbi.nlm.nih.gov/pubmed/25383924
http://dx.doi.org/10.7554/eLife.04553

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