Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

Epigenetic modifiers are an emerging class of anti-tumor drugs, potent in multiple cancer contexts. Their effect on spontaneously developing autoimmune diseases has been little explored. We report that a short treatment with I-BET151, a small-molecule inhibitor of a family of bromodomain-containing...

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Detalles Bibliográficos
Autores principales: Fu, Wenxian, Farache, Julia, Clardy, Susan M, Hattori, Kimie, Mander, Palwinder, Lee, Kevin, Rioja, Inmaculada, Weissleder, Ralph, Prinjha, Rab K, Benoist, Christophe, Mathis, Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270084/
https://www.ncbi.nlm.nih.gov/pubmed/25407682
http://dx.doi.org/10.7554/eLife.04631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270084/
https://www.ncbi.nlm.nih.gov/pubmed/25407682
http://dx.doi.org/10.7554/eLife.04631

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